Non-Hematopoietic MLKL Protects Against Salmonella Mucosal Infection by Enhancing Inflammasome Activation

The intestinal mucosal barrier is critical for host defense against pathogens infection. Here, we demonstrate that the mixed lineage kinase-like protein (MLKL), a necroptosis effector, promotes intestinal epithelial barrier function by enhancing inflammasome activation. MLKL(−/−) mice were more susc...

詳細記述

保存先:
書誌詳細
出版年:Front Immunol
主要な著者: Yu, Shui-Xing, Chen, Wei, Liu, Zhen-Zhen, Zhou, Feng-Hua, Yan, Shi-Qing, Hu, Gui-Qiu, Qin, Xiao-Xia, Zhang, Jie, Ma, Ke, Du, Chong-Tao, Gu, Jing-Min, Deng, Xu-Ming, Han, Wen-Yu, Yang, Yong-Jun
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2018
主題:
Immunology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801401/
https://ncbi.nlm.nih.gov/pubmed/29456533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00119
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