Non-Hematopoietic MLKL Protects Against Salmonella Mucosal Infection by Enhancing Inflammasome Activation

The intestinal mucosal barrier is critical for host defense against pathogens infection. Here, we demonstrate that the mixed lineage kinase-like protein (MLKL), a necroptosis effector, promotes intestinal epithelial barrier function by enhancing inflammasome activation. MLKL(−/−) mice were more susc...

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Bibliografski detalji
Izdano u:Front Immunol
Glavni autori: Yu, Shui-Xing, Chen, Wei, Liu, Zhen-Zhen, Zhou, Feng-Hua, Yan, Shi-Qing, Hu, Gui-Qiu, Qin, Xiao-Xia, Zhang, Jie, Ma, Ke, Du, Chong-Tao, Gu, Jing-Min, Deng, Xu-Ming, Han, Wen-Yu, Yang, Yong-Jun
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Immunology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801401/
https://ncbi.nlm.nih.gov/pubmed/29456533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00119
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