Catechol-O-Methyltransferase (COMT) Genotype Affects Cognitive Control during Total Sleep Deprivation

Adaptive decision making is profoundly impaired by total sleep deprivation (TSD). This suggests that TSD impacts fronto-striatal pathways involved in cognitive control, where dopamine is a key neuromodulator. In the prefrontal cortex (PFC), dopamine is catabolized by the enzyme catechol-O-methyltran...

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Detalhes bibliográficos
Publicado no:Cortex
Main Authors: Satterfield, Brieann C., Hinson, John M., Whitney, Paul, Schmidt, Michelle A., Wisor, Jonathan P., Van Dongen, Hans P.A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801055/
https://ncbi.nlm.nih.gov/pubmed/29248857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cortex.2017.11.012
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