DENTATE NETWORK ACTIVITY IS NECESSARY FOR SPATIAL WORKING MEMORY BY SUPPORTING CA3 SHARP-WAVE RIPPLE GENERATION AND PROSPECTIVE FIRING OF CA3 NEURONS

Complex spatial working memory (WM) tasks have been shown to require both hippocampal sharp wave ripple (SWR) activity and dentate gyrus (DG) neuronal activity. We therefore asked whether DG inputs to CA3 contribute to spatial WM by promoting SWR generation. Recordings from DG and CA3 while rats per...

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Vydáno v:Nat Neurosci
Hlavní autoři: Sasaki, Takuya, Piatti, Verónica C., Hwaun, Ernie, Ahmadi, Siavash, Lisman, John E., Leutgeb, Stefan, Leutgeb, Jill K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800997/
https://ncbi.nlm.nih.gov/pubmed/29335604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-017-0061-5
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