Inducible transgenic expression of tripeptidyl peptidase 1 in a mouse model of late-infantile neuronal ceroid lipofuscinosis

Late-infantile neuronal ceroid lipofuscinosis is a fatal neurodegenerative disease of children caused by mutations resulting in loss of activity of the lysosomal protease, tripeptidyl peptidase 1 (TPP1). While Tpp1-targeted mouse models of LINCL exist, the goal of this study was to create a transgen...

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Veröffentlicht in:PLoS One
Hauptverfasser: Nemtsova, Yuliya, Wiseman, Jennifer A., El-Banna, Mukarram, Lobel, Peter, Sleat, David E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800698/
https://ncbi.nlm.nih.gov/pubmed/29408933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192286
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