Amnionless-mediated glycosylation is crucial for cell surface targeting of cubilin in renal and intestinal cells

Mutations in either cubilin (CUBN) or amnionless (AMN) genes cause Imerslund–Gräsbeck syndrome (IGS), a hereditary disease characterised by anaemia attributed to selective intestinal malabsorption of cobalamin and low-molecular weight proteinuria. Although cubilin protein does not have a transmembra...

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Foilsithe in:Sci Rep
Main Authors: Udagawa, Tomohiro, Harita, Yutaka, Miura, Kenichiro, Mitsui, Jun, Ode, Koji L., Morishita, Shinichi, Urae, Seiya, Kanda, Shoichiro, Kajiho, Yuko, Tsurumi, Haruko, Ueda, Hiroki R., Tsuji, Shoji, Saito, Akihiko, Oka, Akira
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799345/
https://ncbi.nlm.nih.gov/pubmed/29402915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20731-4
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