Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut. The pilus rod, comprised of repeating FimA subunits, provides a structural scaffold for displaying the tip adhesin, FimH. We solved...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Spaulding, Caitlin N, Schreiber, Henry Louis, Zheng, Weili, Dodson, Karen W, Hazen, Jennie E, Conover, Matt S, Wang, Fengbin, Svenmarker, Pontus, Luna-Rico, Areli, Francetic, Olivera, Andersson, Magnus, Hultgren, Scott, Egelman, Edward H
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798934/
https://ncbi.nlm.nih.gov/pubmed/29345620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31662
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