ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells

Loss of organelle homeostasis is a hallmark of aging. However, it remains elusive how this occurs at gene expression level. Here, we report that human mesenchymal stem cell (hMSC) aging is associated with dysfunction of double-membrane organelles and downregulation of transcription factor ATF6. CRIS...

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Vydáno v:Cell Discov
Hlavní autoři: Wang, Si, Hu, Boqiang, Ding, Zhichao, Dang, Yujiao, Wu, Jun, Li, Di, Liu, Xiaoling, Xiao, Bailong, Zhang, Weiqi, Ren, Ruotong, Lei, Jinghui, Hu, Huifang, Chen, Chang, Chan, Piu, Li, Dong, Qu, Jing, Tang, Fuchou, Liu, Guang-Hui
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798892/
https://ncbi.nlm.nih.gov/pubmed/29423270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-017-0003-0
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