Active-site copper reduction promotes substrate binding of fungal lytic polysaccharide monooxygenase and reduces stability

Lytic polysaccharide monooxygenases (LPMOs) are a class of copper-containing enzymes that oxidatively degrade insoluble plant polysaccharides and soluble oligosaccharides. Upon reductive activation, they cleave the substrate and promote biomass degradation by hydrolytic enzymes. In this study, we em...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Kracher, Daniel, Andlar, Martina, Furtmüller, Paul G., Ludwig, Roland
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798298/
https://ncbi.nlm.nih.gov/pubmed/29259126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000109
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