Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a pediatric genetic disease, characterized by motor neuron (MN) death, leading to progressive muscle weakness, respiratory failure, and, in the most severe cases, to death. Abnormalities at the neuromuscular junction (NMJ) have been reported in SMA, including neurofi...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Boido, Marina, De Amicis, Elena, Valsecchi, Valeria, Trevisan, Marco, Ala, Ugo, Ruegg, Markus A., Hettwer, Stefan, Vercelli, Alessandro
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797594/
https://ncbi.nlm.nih.gov/pubmed/29440993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00017
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