Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a pediatric genetic disease, characterized by motor neuron (MN) death, leading to progressive muscle weakness, respiratory failure, and, in the most severe cases, to death. Abnormalities at the neuromuscular junction (NMJ) have been reported in SMA, including neurofi...

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Bibliografiske detaljer
Udgivet i:Front Cell Neurosci
Main Authors: Boido, Marina, De Amicis, Elena, Valsecchi, Valeria, Trevisan, Marco, Ala, Ugo, Ruegg, Markus A., Hettwer, Stefan, Vercelli, Alessandro
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797594/
https://ncbi.nlm.nih.gov/pubmed/29440993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00017
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