Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice

Major depressive disorder is associated with abnormalities in the brain and the immune system. Chronic stress in animals showed that epigenetic and inflammatory mechanisms play important roles in mediating resilience and susceptibility to depression. Here, through a high-throughput screening, we ide...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Wang, Jun, Hodes, Georgia E., Zhang, Hongxing, Zhang, Song, Zhao, Wei, Golden, Sam A., Bi, Weina, Menard, Caroline, Kana, Veronika, Leboeuf, Marylene, Xie, Marc, Bregman, Dana, Pfau, Madeline L., Flanigan, Meghan E., Esteban-Fernández, Adelaida, Yemul, Shrishailam, Sharma, Ali, Ho, Lap, Dixon, Richard, Merad, Miriam, Han, Ming-Hu, Russo, Scott J., Pasinetti, Giulio M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797143/
https://ncbi.nlm.nih.gov/pubmed/29396460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02794-5
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