The natural anti-tumor compound Celastrol targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression

Myb is a key regulator of hematopoietic progenitor cell proliferation and differentiation and has emerged as a potential target for the treatment of acute leukemia. Using a myeloid cell line with a stably integrated Myb-inducible reporter gene as a screening tool we have previously identified Celast...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Coulibaly, Anna, Haas, Astrid, Steinmann, Simone, Jakobs, Anke, Schmidt, Thomas J., Klempnauer, Karl-Heinz
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796697/
https://ncbi.nlm.nih.gov/pubmed/29394256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190934
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