CPT-11-Induced Delayed Diarrhea Develops via Reduced Aquaporin-3 Expression in the Colon

While irinotecan (CPT-11) has a potent anti-cancer effect, it also causes serious diarrhea as an adverse reaction. In this study, we analyzed the pathogenic mechanism of CPT-11-induced delayed diarrhea by focusing on water channel aquaporin-3 (AQP3) in the colon. When rats received CPT-11, the expre...

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Pubblicato in:Int J Mol Sci
Autori principali: Kon, Risako, Tsubota, Yuika, Minami, Moe, Kato, Saki, Matsunaga, Yukari, Kimura, Hiroshi, Murakami, Yuta, Fujikawa, Tetsuya, Sakurai, Ryoya, Tomimoto, Rei, Machida, Yoshiaki, Ikarashi, Nobutomo, Sugiyama, Kiyoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796119/
https://ncbi.nlm.nih.gov/pubmed/29316651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19010170
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