CYP2D6 activity and the risk of recurrence of Plasmodium vivax malaria in the Brazilian Amazon: a prospective cohort study

BACKGROUND: CYP2D6 pathway mediates the activation of primaquine into active metabolite(s) in hepatocytes. CYP2D6 is highly polymorphic, encoding CYP2D6 isoforms with normal, reduced, null or increased activity. It is hypothesized that Plasmodium vivax malaria patients with defective CYP2D6 function...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Brasil, Larissa W., Rodrigues-Soares, Fernanda, Santoro, Ana B., Almeida, Anne C. G., Kühn, Andrea, Ramasawmy, Rajendranath, Lacerda, Marcus V. G., Monteiro, Wuelton M., Suarez-Kurtz, Guilherme
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5795836/
https://ncbi.nlm.nih.gov/pubmed/29390987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-017-2139-7
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