β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation

β-Sitosterol (BS), a major bioactive constituent present in plants and vegetables has shown potent anticancer effect against many human cancer cells, but the underlying mechanism remain elusive on NSCLC cancers. We found that BS significantly inhibited the growth of A549 cells without harming normal...

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Foilsithe in:Sci Rep
Main Authors: Rajavel, Tamilselvam, Packiyaraj, Pandian, Suryanarayanan, Venkatesan, Singh, Sanjeev Kumar, Ruckmani, Kandasamy, Pandima Devi, Kasi
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794769/
https://ncbi.nlm.nih.gov/pubmed/29391428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20311-6
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