Detecting differential copy number variation between groups of samples

We present a method to detect copy number variants (CNVs) that are differentially present between two groups of sequenced samples. We use a finite-state transducer where the emitted read depth is conditioned on the mappability and GC-content of all reads that occur at a given base position. In this...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genome Res
Prif Awduron: Lowe, Craig B., Sanchez-Luege, Nicelio, Howes, Timothy R., Brady, Shannon D., Daugherty, Rhea R., Jones, Felicity C., Bell, Michael A., Kingsley, David M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2018
Pynciau:
Method
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5793789/
https://ncbi.nlm.nih.gov/pubmed/29229672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.206938.116
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