Delivery of VEGFA in bone marrow stromal cells seeded in copolymer scaffold enhances angiogenesis, but is inadequate for osteogenesis as compared with the dual delivery of VEGFA and BMP2 in a subcutaneous mouse model

BACKGROUND: In bone tissue engineering (BTE), extensive research into vascular endothelial growth factor A (VEGFA)-mediated angiogenesis has yielded inconsistent results. The aim of this study was to investigate the influence on angio- and osteogenesis of adenoviral-mediated delivery of VEGFA alone...

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Dettagli Bibliografici
Pubblicato in:Stem Cell Res Ther
Autori principali: Sharma, Sunita, Sapkota, Dipak, Xue, Ying, Rajthala, Saroj, Yassin, Mohammed A., Finne-Wistrand, Anna, Mustafa, Kamal
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5793460/
https://ncbi.nlm.nih.gov/pubmed/29386057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-018-0778-4
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