Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3

Tumor suppressor and upstream master kinase Liver kinase B1 (LKB1) plays a significant role in suppressing cancer growth and metastatic progression. We show that low-LKB1 expression significantly correlates with poor survival outcome in breast cancer. In line with this observation, loss-of-LKB1 rend...

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Vydáno v:Oncogene
Hlavní autoři: Sengupta, S, Nagalingam, A, Muniraj, N, Bonner, MY, Mistriotis, P, Afthinos, A, Kuppusamy, P, Lanoue, D, Cho, S, Korangath, P, Shriver, M, Begum, A, Merino, VF, Huang, C-Y, Arbiser, JL, Matsui, W, Győrffy, B, Konstantopoulos, K, Sukumar, S, Marignani, PA, Saxena, NK, Sharma, D
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5793218/
https://ncbi.nlm.nih.gov/pubmed/28581518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.164
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