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Linking DNA Damage and Age-Related Promoter DNA Hyper-Methylation in the Intestine
Aberrant DNA methylation in stem cells is a hallmark of aging and tumor development. Here, we explore whether and how DNA damage repair might impact on these time-dependent changes, in particular in proliferative intestinal stem cells. We introduce a 3D multiscale computer model of intestinal crypts...
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| Publicado no: | Genes (Basel) |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5793170/ https://ncbi.nlm.nih.gov/pubmed/29303998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes9010017 |
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