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The Bioactive Extract of Pinnigorgia sp. Induces Apoptosis of Hepatic Stellate Cells via ROS-ERK/JNK-Caspase-3 Signaling

The activation of hepatic stellate cells (HSCs) is a significant phenomenon during the pathogenesis of liver disorders, including liver cirrhosis and fibrosis. Here, we identified that the extract from a gorgonian coral Pinnigorgia sp. (Pin) induced apoptosis of HSC-T6 cells. Pin inhibited the viabi...

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Bibliografiske detaljer
Udgivet i:Mar Drugs
Main Authors: Kuo, Liang-Mou, Chen, Po-Jen, Sung, Ping-Jyun, Chang, Yu-Chia, Ho, Chun-Ting, Wu, Yi-Hsiu, Hwang, Tsong-Long
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5793067/
https://ncbi.nlm.nih.gov/pubmed/29315209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md16010019
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