Programmed Death-1 Blockade With Pembrolizumab in Patients With Classical Hodgkin Lymphoma After Brentuximab Vedotin Failure

PURPOSE: Classical Hodgkin lymphoma (HL) frequently exhibits genetic alterations leading to overexpression of the programmed death-1 (PD-1) ligands, suggesting a possible vulnerability to PD-1 blockade. The phase Ib study KEYNOTE-013 (NCT01953692) tested the safety and efficacy of the anti–PD-1 anti...

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Veröffentlicht in:J Clin Oncol
Hauptverfasser: Armand, Philippe, Shipp, Margaret A., Ribrag, Vincent, Michot, Jean-Marie, Zinzani, Pier Luigi, Kuruvilla, John, Snyder, Ellen S., Ricart, Alejandro D., Balakumaran, Arun, Rose, Shelonitda, Moskowitz, Craig H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Clinical Oncology 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791838/
https://ncbi.nlm.nih.gov/pubmed/27354476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2016.67.3467
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