Integrin-uPAR signaling leads to FRA-1 phosphorylation and enhanced breast cancer invasion

BACKGROUND: The Fos-related antigen 1 (FRA-1) transcription factor promotes tumor cell growth, invasion and metastasis. Phosphorylation of FRA-1 increases protein stability and function. We identify a novel signaling axis that leads to increased phosphorylation of FRA-1, increased extracellular matr...

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Dettagli Bibliografici
Pubblicato in:Breast Cancer Res
Autori principali: Annis, Matthew G., Ouellet, Veronique, Rennhack, Jonathan P., L’Esperance, Sylvain, Rancourt, Claudine, Mes-Masson, Anne-Marie, Andrechek, Eran R., Siegel, Peter M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791353/
https://ncbi.nlm.nih.gov/pubmed/29382358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-018-0936-8
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