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Clinical Implications of Digenic Inheritance and Epistasis in Primary Immunodeficiency Disorders
The existence of epistasis in humans was first predicted by Bateson in 1909. Epistasis describes the non-linear, synergistic interaction of two or more genetic loci, which can substantially modify disease severity or result in entirely new phenotypes. The concept has remained controversial in human...
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| Publicado no: | Front Immunol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5790765/ https://ncbi.nlm.nih.gov/pubmed/29434582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01965 |
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