Signaling by the Epstein–Barr virus LMP1 protein induces potent cytotoxic CD4(+) and CD8(+) T cell responses

The B-lymphotropic Epstein–Barr virus (EBV), pandemic in humans, is rapidly controlled on initial infection by T cell surveillance; thereafter, the virus establishes a lifelong latent infection in the host. If surveillance fails, fatal lymphoproliferation and lymphomagenesis ensue. The initial T cel...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Choi, Il-Kyu, Wang, Zhe, Ke, Qiang, Hong, Min, Qian, Yu, Zhao, Xiujuan, Liu, Yuting, Kim, Hye-Jung, Ritz, Jerome, Cantor, Harvey, Rajewsky, Klaus, Wucherpfennig, Kai W., Zhang, Baochun
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789919/
https://ncbi.nlm.nih.gov/pubmed/29311309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713607115
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