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Chromosome conformation signatures define predictive markers of inadequate response to methotrexate in early rheumatoid arthritis

BACKGROUND: There is a pressing need in rheumatoid arthritis (RA) to identify patients who will not respond to first-line disease-modifying anti-rheumatic drugs (DMARD). We explored whether differences in genomic architecture represented by a chromosome conformation signature (CCS) in blood taken fr...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Carini, Claudio, Hunter, Ewan, Ramadass, Aroul S., Green, Jayne, Akoulitchev, Alexandre, McInnes, Iain B., Goodyear, Carl S.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789697/
https://ncbi.nlm.nih.gov/pubmed/29378619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1387-9
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