Sequential BMP7/TGF-β1 signaling and microbiota instruct mucosal Langerhans cell differentiation

Mucosal Langerhans cells (LCs) originate from pre–dendritic cells and monocytes. However, the mechanisms involved in their in situ development remain unclear. Here, we demonstrate that the differentiation of murine mucosal LCs is a two-step process. In the lamina propria, signaling via BMP7-ALK3 pro...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Capucha, Tal, Koren, Noam, Nassar, Maria, Heyman, Oded, Nir, Tsipora, Levy, Maayan, Zilberman-Schapira, Gili, Zelentova, Katya, Eli-Berchoer, Luba, Zenke, Martin, Hieronymus, Thomas, Wilensky, Asaf, Bercovier, Herve, Elinav, Eran, Clausen, Björn E., Hovav, Avi-Hai
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789418/
https://ncbi.nlm.nih.gov/pubmed/29343501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171508
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados