The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders

Currently, there are no specific therapies to treat HIV-1 associated neurocognitive disorders (HAND). The HIV-1 envelope, gp120, induces neuropathological changes similar to those in HAND patients; furthermore, it triggers an upregulation of the α7-nicotinic acetylcholine receptor (α7-nAChR), facili...

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Published in:Sci Rep
Main Authors: Capó-Vélez, Coral M., Morales-Vargas, Bryan, García-González, Aurian, Grajales-Reyes, José G., Delgado-Vélez, Manuel, Madera, Bismark, Báez-Pagán, Carlos A., Quesada, Orestes, Lasalde-Dominicci, José A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788855/
https://ncbi.nlm.nih.gov/pubmed/29379089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20271-x
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