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Enhanced susceptibility to stress and seizures in GAD65 deficient mice
Reduced gamma-aminobutyric acid (GABA) inhibition has been implicated in both anxiety and epilepsy. GAD65(-/-) (NOD/LtJ) mice have significantly decreased basal GABA levels in the brain and a lowered threshold for seizure generation. One fifth of GAD65 (-/-) mice experienced stress-induced seizures...
Shranjeno v:
| izdano v: | PLoS One |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5788371/ https://ncbi.nlm.nih.gov/pubmed/29377906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191794 |
| Oznake: |
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