Enhanced susceptibility to stress and seizures in GAD65 deficient mice

Reduced gamma-aminobutyric acid (GABA) inhibition has been implicated in both anxiety and epilepsy. GAD65(-/-) (NOD/LtJ) mice have significantly decreased basal GABA levels in the brain and a lowered threshold for seizure generation. One fifth of GAD65 (-/-) mice experienced stress-induced seizures...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Qi, Jin, Kim, Minjung, Sanchez, Russell, Ziaee, Saba M, Kohtz, Jhumku D, Koh, Sookyong
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788371/
https://ncbi.nlm.nih.gov/pubmed/29377906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191794
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