Inhibition of Cocaine and 3,4-Methylenedioxypyrovalerone (MDPV) Self-Administration by Lorcaserin Is Mediated by 5-HT2C Receptors in Rats

Lorcaserin is a serotonin (5-HT)(2C) receptor-preferring agonist approved by the US Food and Drug Administration to treat obesity. Lorcaserin decreases cocaine self-administration in rats and monkeys. Although this effect is partially inhibited by a 5-HT(2C) receptor antagonist (SB242084), lorcaseri...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Gannon, Brenda M., Sulima, Agnieszka, Rice, Kenner C., Collins, Gregory T.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
Assuntos:
Behavioral Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787931/
https://ncbi.nlm.nih.gov/pubmed/29217539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.246082
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