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Organelle luminal dependence of (+)strand RNA virus replication reveals a hidden druggable target
Positive-strand RNA viruses replicate their genomes in membrane-bounded cytoplasmic complexes. We show that endoplasmic reticulum (ER)–linked genomic RNA replication by brome mosaic virus (BMV), a well-studied member of the alphavirus superfamily, depends on the ER luminal thiol oxidase ERO1. We fur...
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| Publicado no: | Sci Adv |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5787378/ https://ncbi.nlm.nih.gov/pubmed/29387794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aap8258 |
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