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PA5470 Counteracts Antimicrobial Effect of Azithromycin by Releasing Stalled Ribosome in Pseudomonas aeruginosa

Pseudomonas aeruginosa causes various acute and chronic infections in humans. Treatment with azithromycin (AZM) has been shown to benefit patients with chronic P. aeruginosa infections. By binding to the exit tunnel of the 50S ribosome, AZM causes ribosome stalling and depletion of the intracellular...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Shi, Jing, Liu, Yiwei, Zhang, Yueying, Jin, Yongxin, Bai, Fang, Cheng, Zhihui, Jin, Shouguang, Wu, Weihui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786749/
https://ncbi.nlm.nih.gov/pubmed/29203495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01867-17
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