A trivalent Apx-fusion protein delivered by E. coli outer membrane vesicles induce protection against Actinobacillus pleuropneumoniae of serotype 1 and 7 challenge in a murine model

Actinobacillus pleuropneumoniae (APP) causes serious economic losses in the swine industry, and is the etiologic agent of porcine pleuropneumonia. In this study we have engineered a trivalent Apx fusion protein enclosed in outer membrane vesicles (Apxr-OMV) and studied its immunoprotective efficacy...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Xu, Kui, Zhao, Qin, Wen, Xintian, Wu, Rui, Wen, Yiping, Huang, Xiaobo, Huang, Yong, Yan, Qigui, Han, Xinfeng, Ma, Xiaoping, Chang, Yung-Fu, Cao, Sanjie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786296/
https://ncbi.nlm.nih.gov/pubmed/29373591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191286
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