Ribosome Incorporation into Somatic Cells Promotes Lineage Transdifferentiation towards Multipotency

Recently, we reported that bacterial incorporation induces cellular transdifferentiation of human fibroblasts. However, the bacterium-intrinsic cellular- transdifferentiation factor remained unknown. Here, we found that cellular transdifferentiation is caused by ribosomes. Ribosomes, isolated from b...

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Udgivet i:Sci Rep
Main Authors: Ito, Naofumi, Katoh, Kaoru, Kushige, Hiroko, Saito, Yutaka, Umemoto, Terumasa, Matsuzaki, Yu, Kiyonari, Hiroshi, Kobayashi, Daiki, Soga, Minami, Era, Takumi, Araki, Norie, Furuta, Yasuhide, Suda, Toshio, Kida, Yasuyuki, Ohta, Kunimasa
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786109/
https://ncbi.nlm.nih.gov/pubmed/29374279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20057-1
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