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An xQTL map integrates the genetic architecture of the human brain’s transcriptome and epigenome

We report a novel multi-omic resource generated by applying quantitative trait locus (xQTL) analyses to RNA sequence, DNA methylation, and histone acetylation data from the dorsolateral prefrontal cortex of 411 older adult individuals that have all three data types. We identify SNPs significantly as...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Ng, B, White, CC, Klein, H, Sieberts, SK, McCabe, C, Patrick, E, Xu, J, Yu, L, Gaiteri, C, Bennett, DA, Mostafavi, S, De Jager, PL
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785926/
https://ncbi.nlm.nih.gov/pubmed/28869584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4632
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