Prostaglandin receptors induce urothelial tumourigenesis as well as bladder cancer progression and cisplatin resistance presumably via modulating PTEN expression

BACKGROUND: We investigated the role of prostaglandin receptors (e.g. prostaglandin E2 receptor 2 (EP2), EP4) and the efficacy of celecoxib in urothelial tumourigenesis and cancer progression. METHODS: We performed immunohistochemistry in bladder cancer (BC) tissue microarrays, in vitro transformati...

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Dettagli Bibliografici
Pubblicato in:Br J Cancer
Autori principali: Kashiwagi, Eiji, Inoue, Satoshi, Mizushima, Taichi, Chen, Jinbo, Ide, Hiroki, Kawahara, Takashi, Reis, Leonardo O, Baras, Alexander S, Netto, George J, Miyamoto, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2018
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785746/
https://ncbi.nlm.nih.gov/pubmed/29123257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.393
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