MYC regulation of glutamine–proline regulatory axis is key in luminal B breast cancer

BACKGROUND: Altered cellular metabolism is a hallmark of cancer and some are reliant on glutamine for sustained proliferation and survival. We hypothesise that the glutamine–proline regulatory axis has a key role in breast cancer (BC) in the highly proliferative classes. METHODS: Glutaminase (GLS),...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Craze, Madeleine L, Cheung, Hayley, Jewa, Natasha, Coimbra, Nuno D M, Soria, Daniele, El-Ansari, Rokaya, Aleskandarany, Mohammed A, Wai Cheng, Kiu, Diez-Rodriguez, Maria, Nolan, Christopher C, Ellis, Ian O, Rakha, Emad A, Green, Andrew R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785743/
https://ncbi.nlm.nih.gov/pubmed/29169183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.387
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