Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons

Mitochondrial changes have long been implicated in the pathogenesis of Parkinson's disease (PD). The glycine to serine mutation (G2019S) in leucine-rich repeat kinase 2 (LRRK2) is the most common genetic cause for PD and has been shown to impair mitochondrial function and morphology in multiple...

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Udgivet i:Stem Cell Reports
Main Authors: Schwab, Andrew J., Sison, Samantha L., Meade, Michael R., Broniowska, Katarzyna A., Corbett, John A., Ebert, Allison D.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785678/
https://ncbi.nlm.nih.gov/pubmed/29129681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.10.010
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