Non-monotonic Changes in Progenitor Cell Behavior and Gene Expression during Aging of the Adult V-SVZ Neural Stem Cell Niche

Neural stem cell activity in the ventricular-subventricular zone (V-SVZ) decreases with aging, thought to occur by a unidirectional decline. However, by analyzing the V-SVZ transcriptome of male mice at 2, 6, 18, and 22 months, we found that most of the genes that change significantly over time show...

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Pubblicato in:Stem Cell Reports
Autori principali: Apostolopoulou, Maria, Kiehl, Thomas R., Winter, Mark, Cardenas De La Hoz, Edgar, Boles, Nathan C., Bjornsson, Christopher S., Zuloaga, Kristen L., Goderie, Susan K., Wang, Yue, Cohen, Andrew R., Temple, Sally
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785674/
https://ncbi.nlm.nih.gov/pubmed/29129683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.10.005
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