Retinoic acid prevents immunogenicity of milk lipocalin Bos d 5 through binding to its immunodominant T-cell epitope

The major cow’s milk allergen Bos d 5 belongs to the lipocalin protein family, with an intramolecular pocket for hydrophobic ligands. We investigated whether Bos d 5 when loaded with the active vitamin A metabolite retinoic acid (RA), would elicit differential immune responses compared to the unload...

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Vydáno v:Sci Rep
Hlavní autoři: Hufnagl, Karin, Ghosh, Debajyoti, Wagner, Stefanie, Fiocchi, Alessandro, Dahdah, Lamia, Bianchini, Rodolfo, Braun, Nina, Steinborn, Ralf, Hofer, Martin, Blaschitz, Marion, Roth, Georg A., Hofstetter, Gerlinde, Roth-Walter, Franziska, Pacios, Luis F., Jensen-Jarolim, Erika
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785490/
https://ncbi.nlm.nih.gov/pubmed/29371615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19883-0
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