Vascular Semaphorin 7A upregulation by disturbed flow promotes atherosclerosis through endothelial β1 integrin

OBJECTIVE: Accumulating evidence suggests a role of semaphorins in vascular homeostasis. Here we investigate the role of semaphorin 7A (Sema7A) in atherosclerosis and its underlying mechanism. APPROACH AND RESULTS: Using genetically-engineered Sema7A(−/−)ApoE(−/−) mice, we showed that deletion of Se...

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Publicado en:Arterioscler Thromb Vasc Biol
Main Authors: Hu, Shuhong, Liu, Yifei, You, Tao, Heath, Jack, Xu, Linru, Zheng, Xiaowei, Wang, Aili, Wang, Yinyan, Li, Fengchan, Yang, Fei, Cao, Yiren, Zhang, Huayu, van Gils, Janine M., van Zonneveld, Anton Jan, Jo, Hanjoong, Wu, Qingyu, Zhang, Yonghong, Tang, Chaojun, Zhu, Li
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785426/
https://ncbi.nlm.nih.gov/pubmed/29269512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.310491
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