New 2-Aryl-9-methyl-β-carbolinium salts as Potential Acetylcholinesterase Inhibitor agents: Synthesis, Bioactivity and Structure–Activity Relationship

A series of 2-aryl-9-methyl-β-carbolinium bromides (B) were synthesized and explored for anti-acetylcholinesterase (AChE) activities in vitro, action mechanism and structure-activity relationship. All the compounds B along with their respective 3,4-dihydro intermediates (A) presented anti-AChE activ...

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Publicat a:Sci Rep
Autors principals: Zhou, Bohang, Zhang, Bingyu, Li, Xingqiang, Liu, Xiuxiu, Li, Hui, Li, Ding, Cui, Zhiming, Geng, Huiling, Zhou, Le
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784158/
https://ncbi.nlm.nih.gov/pubmed/29367595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19999-3
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