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Tryptophan hydroxylase (TRH) loss of function mutations induce growth and behavioral defects in Daphnia magna
Tryptophan hydroxylase (TRH) is the rate limiting enzyme in the serotonin synthesis. CRISPR-Cas9 technology was used to generate seven indel TRH mutants in Daphnia magna. Mono-allelic indel TRH−/+ clones showed normal levels of serotonin, measured by both immunohistochemistry and mass spectrometry (...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5784079/ https://ncbi.nlm.nih.gov/pubmed/29367674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19778-0 |
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