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Evolution of telomere maintenance and tumour suppressor mechanisms across mammals
Mammalian species differ dramatically in telomere biology. Species larger than 5–10 kg repress somatic telomerase activity and have shorter telomeres, leading to replicative senescence. It has been proposed that evolution of replicative senescence in large-bodied species is an anti-tumour mechanism...
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| Publicado en: | Philos Trans R Soc Lond B Biol Sci |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Royal Society
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5784063/ https://ncbi.nlm.nih.gov/pubmed/29335367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2016.0443 |
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