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Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit
Duplexed aptamers (DAs) are ligand-responsive constructs engineered by hybridizing an aptamer with an aptamer-complementary element (ACE, e.g., a DNA oligonucleotide). Although DAs are commonly deployed, the binding dynamics of ternary ACE-aptamer–ligand systems remain underexplored, having been con...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5783947/ https://ncbi.nlm.nih.gov/pubmed/29367662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02556-3 |
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