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The role of brigatinib in crizotinib-resistant non-small cell lung cancer

Despite the advances in new targeted therapies in ALK positive population, most patients progress under ALK inhibitors within first 2 years; being the brain the most frequent site of relapse. ALK mutations, in ~30% of patients, are the main known mechanism of resistance. Classically, second-generati...

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Detalhes bibliográficos
Publicado no:Cancer Manag Res
Main Authors: Mezquita, Laura, Planchard, David
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5783011/
https://ncbi.nlm.nih.gov/pubmed/29403310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S129963
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