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P05.02 The Chk1 inhibitor SAR-020106 abrogates the irradiation-induced G2 arrest and enhances the effect of irradiation on the clonogenic survival of human p53-mutant glioblastoma cells
INTRODUCTION: Tumor cells lacking functional p53 protein have a restricted DNA repair capacity especially at the G1/S cell cycle checkpoint. Disruption of DSB repair by inhibition of G1/2 cell cycle checkpoints, together with DNA-damaging agents have recently been recognized as a promising strategy...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5782587/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now188.089 |
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