P05.02 The Chk1 inhibitor SAR-020106 abrogates the irradiation-induced G2 arrest and enhances the effect of irradiation on the clonogenic survival of human p53-mutant glioblastoma cells

INTRODUCTION: Tumor cells lacking functional p53 protein have a restricted DNA repair capacity especially at the G1/S cell cycle checkpoint. Disruption of DSB repair by inhibition of G1/2 cell cycle checkpoints, together with DNA-damaging agents have recently been recognized as a promising strategy...

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Vydáno v:Neuro Oncol
Hlavní autoři: Patties, I., Frisman, M., Kendzia, E., Menzel, F., Gaunitz, F., Kortmann, R., Glasow, A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
P05 In vitro / in vivo models
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5782587/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now188.089
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