Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation

Heavy menstrual bleeding (HMB) is common and debilitating, and often requires surgery due to hormonal side effects from medical therapies. Here we show that transient, physiological hypoxia occurs in the menstrual endometrium to stabilise hypoxia inducible factor 1 (HIF-1) and drive repair of the de...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Maybin, Jacqueline A., Murray, Alison A., Saunders, Philippa T. K., Hirani, Nikhil, Carmeliet, Peter, Critchley, Hilary O. D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5780386/
https://ncbi.nlm.nih.gov/pubmed/29362355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02375-6
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