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Binding, Folding and Insertion of a β-Hairpin Peptide at a Lipid Bi layer Surface: Influence of Electrostatics and Lipid Tail Packing
Antimicrobial peptides (AMPs) act as host defenses against microbial pathogens. Here we investigate the interactions of SVS-1 (KVKVKVKV(D)P(L)PTKVKVKVK), an engineered AMP and anti-cancer β-hairpin peptide, with lipid bilayers using spectroscopic studies and atomistic molecular dynamics simulations....
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| Veröffentlicht in: | Biochim Biophys Acta |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5780206/ https://ncbi.nlm.nih.gov/pubmed/29291379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2017.12.019 |
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