Targeted reversion of induced pluripotent stem cells from patients with human cleidocranial dysplasia improves bone regeneration in a rat calvarial bone defect model

BACKGROUND: Runt-related transcription factor 2 (RUNX2) haploinsufficiency causes cleidocranial dysplasia (CCD) which is characterized by supernumerary teeth, short stature, clavicular dysplasia, and osteoporosis. At present, as a therapeutic strategy for osteoporosis, mesenchymal stem cell (MSC) tr...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Saito, Akiko, Ooki, Akio, Nakamura, Takashi, Onodera, Shoko, Hayashi, Kamichika, Hasegawa, Daigo, Okudaira, Takahito, Watanabe, Katsuhito, Kato, Hiroshi, Onda, Takeshi, Watanabe, Akira, Kosaki, Kenjiro, Nishimura, Ken, Ohtaka, Manami, Nakanishi, Mahito, Sakamoto, Teruo, Yamaguchi, Akira, Sueishi, Kenji, Azuma, Toshifumi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778688/
https://ncbi.nlm.nih.gov/pubmed/29357927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-017-0754-4
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