Modular Three-Component Synthesis of 4-Aminoquinolines via an Imidoylative Sonogashira/Cyclization Cascade

[Image: see text] We developed a one-pot, two-stage synthetic route to substituted 4-aminoquinolines involving an imidoylative Sonogashira coupling followed by acid-mediated cyclization. This three-component reaction affords pharmaceutically valuable 4-aminoquinolines in a one-pot procedure from rea...

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Udgivet i:J Org Chem
Main Authors: Collet, Jurriën W., Ackermans, Kelly, Lambregts, Jeffrey, Maes, Bert U.W., Orru, Romano V.A., Ruijter, Eelco
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778392/
https://ncbi.nlm.nih.gov/pubmed/29260564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.7b02844
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